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The rate of major bleeding while receiving warfarin was 2.3%per year(95% confidence interval[CI],1.7 to 3.2)vs 1.1%per year(95%CI,0.7 to 1.8)while receiving aspirin(relative risk,2.1;95%CI,1.1 to 3.1;P=.02).Intracranial hemorrhage occurred at 0.9%per year(95%CI,0.5 to 1.5)with warfarin and 0. 3%per year(95%CI,0.1 to 0.8)with aspirin(relative risk,2.4 P=.08).Age(P=. 006),increasing number of prescribed medications(P=.007),and intensity of anticoagulation(P=.02)were independent risks for bleeding at any site during anticoagulation.The rate of major hemorrhage was 1.7%per year in patients aged 75 years or younger who received anticoagulation vs 4.2%per year in older patients(relative risk,2.6,P=.009);rates by age for intracranial bleeding were 0.6%per year and 1.8%per year,respectively(P=. 05).Advancing age and more intense anticoagulation increase the risk of major hemorrhage in patients given warfarin for stroke prevention. |
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adverse drug reaction
anticoagulant,complications of
anticoagulant,treatment
atrial fibrillation
cerebrovascular accident,prevention of
coumarin
intracerebral hemorrhage
intracerebral hemorrhage,lobar
intracranial hemorrhage
old age,neurology of
prothrombin time
prothrombin time,prolonged
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